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KMID : 0383820070630050423
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Tuberculosis and Respiratory Diseases
2007 Volume.63 No. 5 p.423 ~ p.429
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The Effect and Safety of Alveolar Recruitment Maneuver using Pressure-Controlled Ventilation in Acute Lung Injury and Acute Respiratory Distress Syndrome
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Jung Kyung-Soo
Park Byung-Hoon
Shin Sang-Yun
Jeon Han-Ho
Park Seon-Cheol
Kang Shin-Myung
Park Moo-Suk
Han Chang-Hoon
Kim Chong-Ju
Lee Sun-Min
Kim Se-Kyu
Chang Joon
Kim Sung-Kyu
Kim Young-Sam
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Abstract
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Background : It is not known with certainty whether patients with persistently positive sputum smear results who have also had negative sputum culture results require prolongation of treatment for tuberculosis in order to avoid an increased risk of eventual relapse. The purpose of the present study was to retrospectively describe the treatment characteristics and evaluate the appropriate duration of treatment in these patients.
Methods : Sixty of 69 patients with sputum smear positive and culture negative tests at 5 months after first line anti-tuberculous chemotherapy from 2002 to 2003 were retrospectively analyzed. Exclusion criteria included incomplete treatment or resistance to rifampicin or two additional antibiotics, as determined by a drug susceptibility test (DST).
Results : Smear conversion of the study subjects was observed after 8.3+/-2.3 months treatment, and the patients were culture negative after 2.0+/-0.8 months. The relapse rates of the study subjects were 3.8, 10.0, and 25.8% after 1, 2, and 5 years of anti-tuberculosis chemotherapy, respectively. The relapse rates were not significantly affected by a series of risk factors such as age, sex, presence of diabetes, a sputum culture examination after 2 months treatment, previous treatment history, chest radiograph, and duration of the treatment (p>0.05).
Conclusion : Regimen change is not required for patients with persistent smear positive but culture negative tests in the fifth month for first line antituberculous treatment. However, a further study will be needed to clarify the high relapse rate in this specific group of patients.
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KEYWORD
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Recruitment maneuvers, Acute Lung injury, Acute respiratory distress syndrome, Pressure-controlled ventilation
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